| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 8:''' stop administration of vortioxetine.| start = {{washout8-14StopSSRI,SNRI}}* '''Day 15:''' | start administration of duloxetine in a dosage of 30 mg/day.= {{Day22NoBloodlevelvortioxetineStartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose duloxetine = 60 mg* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>{{reviewtheorSS}}