Switch medication from vortioxetine to fluvoxamine.
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
- Day 8: start administration of fluvoxamine in a dosage of 50 mg/day.
- Day 22: bloodlevel vortioxetine is now zero, so you can increase faster.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- fluvoxamine is a inhibitor of CYP2C9, which metabolizes vortioxetine.
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