| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.{{StopSSRI,SNRI}}| start = {{StartAntidepressant}}* A wash-out period is not necessary, but care is needed.| info =* '''Day 8:''' Start Safe target dose sertraline the next day in normal dosage of = 50 mg/day. | info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}