| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 8:''' stop administration of vortioxetine.{{StopSSRI,SNRI}}| start = {{StartAntidepressant}}* A wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions.| info =* '''Day 15:''' Start Safe target dose sertraline in a normal dosage of = 50 mg/day. | info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}