| stop = {{stopVortioxetineStopSSRI,SNRI}}| start = {{StartAntidepressant}}* ''' Day 8-14: ''' a wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions.| info =* '''Day 15:''' Start Safe target dose sertraline in a normal dosage of = 50 mg/day. | info =

* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}