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Vortioxetine-sertraline

144 bytes removed, 14:53, 4 November 2015

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* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 8:''' stop administration of vortioxetine.{{stopVortioxetine}}

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* A ''' Day 8-14: ''' a wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions.

* '''Day 15:''' Start sertraline in a normal dosage of 50 mg/day.

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* ~~Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.~~{{theorSS}}

* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}

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