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Zuclopenthixol LA-Amisulpride

Zuclopenthixol
long acting
Type Antipsychotic
Group Thioxanthenes
links
PubChem 5311507
PubMed Zuclopenthixol
Kompas (Dutch) Zuclopenthixol
Wikipedia Zuclopenthixol
Amisulpride
Type Antipsychotic
Group Atypical AP
links
PubChem 2159
PubMed Amisulpride
Wikipedia Amisulpride

Switch medication from Zuclopenthixol_LA to Amisulpride.[1] [2]

Nietinrijdenbord.png Stop Zuclopenthixol_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Amisulpride
  • Week 1-3: approx. 25% of target dose
  • Week 4-6: approx. 50% of target dose
  • Week 7-9: approx. 75% of target dose
  • Week 10: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
    StopDepotStartOral.jpg
Nietinrijdenbord.png — Zuclopenthixol_LA
Eenrichtingbord.png — Amisulpride


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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