Switch medication from amitriptyline to clomipramine.
- Decrease with about 25% of the original dose per 3 days.
- No wash-out period is needed.
- Increase with about 25% of target dose per 3 days.
- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.
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