Imipramine-fluvoxamine
From Psychiatrienet
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Switch medication from imipramine to fluvoxamine[1][2]
Stop imipramine - Day 1: Decrease with about 25% of the original dose per 3 days.
Start fluvoxamine- Day 6: At approximately 50-25% of the original drug dose start fluvoxamine at 50% of the target dose.
- Day 12: Increase dosage of fluvoxamine to 100% of the target dose.
- Day 17: Increase dosage of fluvoxamine if necessary.
More information- Fluvoxamine is an inhibitor of CYP2C19, which metabolize imipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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