Switch medication from imipramine to maprotiline.
- Before day 1: Gradually reduce dosage of imipramine to a maximum of 50-100 mg/day.
- Day 1: when a dosage of 50-100 mg/day is reached, stop administration of imipramine
- No wash-out period is needed.
- Day 2: start administration of maprotiline in a normal dosage of 25-75 mg/day.
- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
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