Maprotiline-duloxetine
From Psychiatrienet
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Switch medication from maprotiline to duloxetine.[1] [2]
Stop maprotiline - Day 1: Decrease with about 25% of the original dose per 3 days.
Start duloxetine- Day 1: Start with 50% of the target dose
- Day 8: Increase dose to 100% of the target dose
- Day 9 and after: Gradually increase dose as necessary
More information- Safe target dose duloxetine = 60 mg
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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