Partial antagonist-Haloperidol LA

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Partial antagonist

Aripiprazole
Brexpiprazole
Cariprazine

Haloperidol
long acting
Type Antipsychotic
Group Butyrophenones
links
ATC-code N05AD01
Medscape Haloperidol
PubChem 3559
PubMed Haloperidol
Drugs.com haloperidol
Kompas (Dutch) Haloperidol
Wikipedia Haloperidol

Switch medication from Partial antagonist to Haloperidol_LA.[4] [5]
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.

Nietinrijdenbord.png Stop Partial antagonist
  • Week 1-6: Continue drug at usual dose
  • Week 7: Stop drug
Eenrichtingbord.png Start Haloperidol_LA
  • Day 1: Start depot according general dosing advice (Dotted line in graph)
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[6]
  • Alternatively, first switch to oral form and then switch to depot to manage possible (adverse) reactions. With a direct switch to a depot it is advisable to administer a low testdose in order to exclude adverse reactions.
    StopArip7WeeksStartDepot.jpg
Nietinrijdenbord.png — Partial antagonist
Eenrichtingbord.png — Haloperidol_LA


  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N05AD01
  2. 2.0 2.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  3. 3.0 3.1 Farmacotherapeutisch Kompas; Inleidende Tekst Antipsychotica (dutch)
  4. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  5. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  6. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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