feedback welcome

Combining-Valproic acid-Topiramate

From Psychiatrynet

(Difference between revisions)
Jump to:navigation, search
[draft revision][draft revision]
(Created page with '{{Drugcombi | base = valproic acid | add = topiramate | info = * Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic a...')
Line 7: Line 7:
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =  
| start =  
-
* Start topiramate according to general dosing advice. Pharmacologic response to the drugs should be monitored more closely following addition or withdrawal of one or the other drug. <ref name="drugscom">{{DRUGSCOM|olanzapine}}</ref>  
+
* Start topiramate according to general dosing advice. Pharmacologic response to the drugs should be monitored more closely following addition or withdrawal of one or the other drug. <ref name="drugscom">{{drugscominteract|topiramate-with-valproic-acid-2216-0-2286-0|valproic acid|topiramate}}</ref>  
| cave =  
| cave =  
* Topiramate has been shown to produce a small but significant increase in valproate clearance, reducing plasma levels.
* Topiramate has been shown to produce a small but significant increase in valproate clearance, reducing plasma levels.
-
* Topiramate plasma levels are increased by about 15% by valproate, which could be important if valproare is withdrawn. <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
+
* Topiramate plasma levels are increased by about 15% by valproate, which could be important if valproic acid is withdrawn.<ref name="bazire"> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
}}
}}

Revision as of 16:31, 5 March 2010

Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid
Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate

Adding topiramate to valproic acid.

Infobord.png General information
Eenrichtingbord.png Start topiramate
Letopbord.png Cave


  1. Interactions between valproic acid and topiramate on drugs.com
  2. Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Navigation
About