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* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according to general dosing advice. Pharmacologic response to the drugs should be monitored more closely following addition or withdrawal of one or the other drug. <ref name="drugscom">{{DRUGSCOMdrugscominteract|olanzapinetopiramate-with-valproic-acid-2216-0-2286-0|valproic acid|topiramate}}</ref>
| cave =
* Topiramate has been shown to produce a small but significant increase in valproate clearance, reducing plasma levels.
* Topiramate plasma levels are increased by about 15% by valproate, which could be important if valproare valproic acid is withdrawn. <ref name=”bazire”"bazire"> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
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