Sertraline-venlafaxine
From Psychiatrienet
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Switch medication from sertraline to venlafaxine.[1] [2]
Stop sertraline - Before day 0: gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of sertraline to 25 mg/day.
- Day 8: stop administration of sertraline.
Start venlafaxine- No wash-out period is needed.
- Day 9: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
Cave- Occurrence of the serotonin syndrome is theoretically possible.
- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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