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* '''Day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
* '''Day 1:''' reduce dosage of duloxetine to a maximum of 30 mg/day.
| start =
A wash-out period of one week is necessary.
* '''Day 8-141:''' washsimultaneously start administration of dosulepine in a low dosage of 25-out period50 mg/day. * '''Day 158:''' start stop administration of dosulepine in a low duloxetine and increase the dosage of 25dosulepine to 50-50 75 mg/day.
| info =
* Duloxetine slows the metabolism of dosulepine by CYP2D6.
* Caution is necessary at the start of administration of dosulepine. }}