Difference between revisions of "Template:CombiCaLa"

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* Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="Koch"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
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* Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase.<ref name="Koch"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
 
* Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref>
 
* Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref>
* Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory). <ref name="freeman" /><ref name="levyrh" />
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* Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory).<ref name="freeman" /><ref name="levyrh" />
* These two agents have less significant pharmacologic interactions than do lamotrigine and valproate <ref name="freeman"/><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref>
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* These two agents have less significant pharmacologic interactions than do lamotrigine and valproate.<ref name="freeman"/><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref>
 
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Latest revision as of 15:33, 23 April 2010

  • Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase.[1]
  • Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.[2][3]
  • Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory).[2][3]
  • These two agents have less significant pharmacologic interactions than do lamotrigine and valproate.[2][3]