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  • Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [1]
  • Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.[2][3]
  • Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory). [2][3]
  • These two agents have less significant pharmacologic interactions than do lamotrigine and valproate [2][3]
  • Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1
  • 2.0 2.1 2.2 Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
  • 3.0 3.1 3.2 Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.