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* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day.
* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.
* '''Day 38:''' reduce stop dosage of amitriptyline to 10 mg/day.
| start =
* '''Day 18:''' simultaneously start administration of fluoxetine in a normal dosage of 20 mg/day.* '''Day 8:''' stop administration of amitriptyline and continue administration of fluoxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.}}
