* '''Day 1:7 and after''' simultaneously : At approximately 50-25% of the original TCA dose start administration of paroxetine in a normal dosage at 50% of 20 mg/daythe target dose.* '''Day 814:''' stop administration Increase paroxetine to 100% of clomipramine and continue administration of paroxetine.the target dose 

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose paroxetine = 20 mg* Paroxetine paroxetine is a strong CYP2D6 inhibitor of CYP2D6, which metabolizes metabolize (desmethyl)clomipramine. }}