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Clomipramine-paroxetine

116 bytes removed, 20 February
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 8:''' stop clomipramine.{{TCAdecrease25p3d}}
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* '''Day 8:7 and after''' : At approximately 50-25% of the original TCA dose start administration paroxetine at 50% of the target dose.* '''Day 14:''' Increase paroxetine in a normal dosage to 100% of 20 mg/day.the target dose 
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose paroxetine = 20 mg* Paroxetine paroxetine is a strong CYP2D6 inhibitor of CYP2D6, which metabolizes metabolize (desmethyl)clomipramine.{{review}}
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