| to = fluoxetine
| stop =
* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 8:''' stop administration of vortioxetine.{{TCAdecrease25p3d}}
| start =
{{Day22NoBloodlevelvortioxetine}}* A wash'''Day 6 and after''': At approximately 50-out period 25% of 2 weeks is necessarythe original vortioxetine dose start fluoxetine at 100% of the target dose.* '''Day 22After 3 weeks:''' start administration If necessary, gradually increase dosage of fluoxetine in a normal dosage of 20 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose fluoxetine = 20 mg* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6(strong), which metabolizes vortioxetine. }}