Changes

{{stopVortioxetineTCAdecrease25p3d}}

* A wash'''Day 6 and after''': At approximately 50-out period 25% of 2 weeks is necessary, because the original vortioxetine dose start fluoxetine at 100% of CYP2D6-inhibitionthe target dose.* '''Day 23After 3 weeks:''' start administration If necessary, gradually increase dosage of fluoxetine in a normal dosage of 20 mg/day.

* {{theorSS}}Safe target dose fluoxetine = 20 mg* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6(strong), which metabolizes vortioxetine. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> }}