| stop = * Gradually reduce dosage of agomelatine to a maximum of 25 mg/day. * When a dosage of 25 mg/day is reached , stop administration.{{StopAgomelatine}}| start = * A wash-out period of one day is necessary.* Start administration of fluvoxamine the next day in a normal dosage of 50 mg/day.{{StartAntidepressant}}

* Safe target dose fluvoxamine = 100 mg* Fluvoxamine stops the metabolism of agomelatine via CYP1A2 and CYP2C9.{{lowlevels}} }}