Difference between revisions of "Sertraline-tranylcypromine"
From Psychiatrienet
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* '''Day 8:''' start tranylcypromine the next day in a low dosage of 20 mg/day for one week. | * '''Day 8:''' start tranylcypromine the next day in a low dosage of 20 mg/day for one week. | ||
* '''Day 15:''' after this week the dosage of tranylcypromine can be increased if necessary. | * '''Day 15:''' after this week the dosage of tranylcypromine can be increased if necessary. | ||
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Revision as of 15:56, 20 July 2009
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Switch medication from sertraline to tranylcypromine.[1] [2]
Stop sertraline - Before day 0: gradually reduce dosage of sertraline to a maximum of 25 mg/day, when this dosage is > 25 mg/day.
- Day 1: stop administration of sertraline.
Start tranylcypromine- Day 1-7: a wash-out period of one week is necessary.
- Day 8: start tranylcypromine the next day in a low dosage of 20 mg/day for one week.
- Day 15: after this week the dosage of tranylcypromine can be increased if necessary.
- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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