Difference between revisions of "Citalopram-fluvoxamine"
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| + | * Fluvoxamine slows the metabolism of (es)citalopram by inhibition of CYP2C19 and CYP3A4 | ||
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Switch medication from citalopram to fluvoxamine.[1] [2]
Stop citalopram - Gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- When a dosage of 20 mg/day, resp. 10 mg/day, is reached, stop administration.
Start fluvoxamine- No wash-out period is needed.
- Start fluvoxamine the next day in normal dosage of 50 mg/day.
More information- The same applies to escitalopram.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluvoxamine slows the metabolism of (es)citalopram by inhibition of CYP2C19 and CYP3A4
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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