Difference between revisions of "Clomipramine-duloxetine"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = duloxetine | | to = duloxetine | ||
| stop = | | stop = | ||
| − | * ''' | + | * '''Day 0:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day. |
| − | * '''Day 1:''' reduce dosage of clomipramine to 25 mg/day. | + | * '''Day 1-7:''' reduce dosage of clomipramine to 25 mg/day. |
| − | * '''Day | + | * '''Day 8:''' stop administration of clomipramine. |
| start = | | start = | ||
| − | * '''Day | + | * '''Day 8-14:''' a wash-out period of one week is necessary. |
| + | * '''Day 15:''' start administration of duloxetine in a normal dosage of 60 mg/day. | ||
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Duloxetine is an inhibitor of CYP2D6, which metabolizes clomipramine. | * Duloxetine is an inhibitor of CYP2D6, which metabolizes clomipramine. | ||
}} | }} | ||
Revision as of 14:22, 4 September 2009
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Switch medication from clomipramine to duloxetine.[1] [2]
Stop clomipramine - Day 0: gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
- Day 1-7: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop administration of clomipramine.
Start duloxetine- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of duloxetine in a normal dosage of 60 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Duloxetine is an inhibitor of CYP2D6, which metabolizes clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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