Difference between revisions of "Combining-Lamotrigine-Risperidone"
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* Risperidone is principally metabolized by CYP2D6 to an active metabolite. | * Risperidone is principally metabolized by CYP2D6 to an active metabolite. | ||
| + | * This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. | ||
| start = | | start = | ||
* Start risperidone according to the general dosing advice. | * Start risperidone according to the general dosing advice. | ||
| cave = | | cave = | ||
* A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref> | * A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref> | ||
| + | * Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. <ref name="drugscom"> | ||
| + | {{Drugscominteract|risperidone-with-lamotrigine-1430-848-2019-1305|risperidone|lamotrigine}}</ref> | ||
}} | }} | ||
Latest revision as of 15:37, 21 April 2010
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Adding risperidone to lamotrigine.
General information- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start risperidone- Start risperidone according to the general dosing advice.
Cave- A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. [7]
- Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. [3]
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
- ↑ 3.0 3.1 Drugs.com lamotrigine Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content - ↑ 4.0 4.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 6.0 6.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2
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