Adding risperidone to lamotrigine.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
- Start risperidone according to the general dosing advice.
- A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. 
- Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. 
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Farmacotherapeutisch Kompas - lamotrigine (dutch)
- Drugs.com lamotrigine Cite error: Invalid
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- KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2
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