Difference between revisions of "Combining-Ziprasidone-Aripiprazole"
From Psychiatrienet
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* Ziprasidone is metabolized by CYP3A4 and CYP1A2 (minor). | * Ziprasidone is metabolized by CYP3A4 and CYP1A2 (minor). | ||
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. | * This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. | ||
Revision as of 13:23, 15 June 2010
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Adding ziprasidone to aripiprazole.
General information- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- Ziprasidone is metabolized by CYP3A4 and CYP1A2 (minor).
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.
Start ziprasidone- Start ziprasidone according to the general dosing advice.
Cave- Agents with anticholinergic properties may have additive effects when used in combination.[1]
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