Combining-Ziprasidone-Aripiprazole

Ariprazole Type Antipsychotic Group Atypical AP Other use moodstabilizer links EMEA abilify PubChem 60975 PubMed Ariprazole Kompas (Dutch) Ariprazole Wikipedia Ariprazole more info

Ziprasidone Type Antipsychotic Group Atypical AP Other use Moodstabilizer links Medscape Ziprasidone PubChem 60854 PubMed Ziprasidone Wikipedia Ziprasidone more info

Adding ziprasidone to aripiprazole.

General information

• Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
• Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.

Start ziprasidone

• The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.

Cave

• Agents with anticholinergic properties may have additive effects when used in combination.

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