Difference between revisions of "Combining-Topiramate-Carbamazepine"
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| − | * Carbamazepine can increase topiramate clearance. | + | * Carbamazepine can increase topiramate clearance. By adding topiramate to carbamazepine no dose adaptation is necessary. <ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name="drugscomint"> |
| − | | cave = | + | {{Drugscominteract|carbamazepine-with-topiramate-2216-0-497-0|carbamazepine|topiramate}}</ref> |
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| + | * This combination of drugs is subject to pharmacokinetic drug interactions. Discontinuation or dose reduction of either drug will need monitoring of the clinical effects and dose adaptation of the drug remained. | ||
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Latest revision as of 12:33, 18 June 2010
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Adding carbamazepine to topiramate.
General information- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
Start carbamazepine- Carbamazepine can increase topiramate clearance. By adding topiramate to carbamazepine no dose adaptation is necessary. [5] [6] [7]
Cave- This combination of drugs is subject to pharmacokinetic drug interactions. Discontinuation or dose reduction of either drug will need monitoring of the clinical effects and dose adaptation of the drug remained.
- ↑ 1.0 1.1 1.2 Farmacotherapeutisch Kompas - topiramaat (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
- ↑ Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
- ↑ Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
- ↑ Interactions between carbamazepine and topiramate on drugs.com
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