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Difference between revisions of "Combining-Carbamazepine-Risperidone"

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{{Drugcombi
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| base = carbamazepine
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| add = risperidone
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| info =
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*
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| start =
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* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
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* Risperidone should be given at higher dosage to control psychotic symptoms.  <ref name="drugscom">
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{{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref> 
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| cave =
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* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref>
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}}

Latest revision as of 10:58, 8 June 2010

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
Eenrichtingbord.png Start risperidone
  • Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
  • Risperidone should be given at higher dosage to control psychotic symptoms. [7]
Letopbord.png Cave
  • Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. [8]


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