Difference between revisions of "Citalopram-hypericum"

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| from = citalopram
 
| from = citalopram
 
| to = hypericum  
 
| to = hypericum  
| stop =  
+
| stop = {{stopCitalopram14d}}
* '''Before day 1:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day, resp. 10 mg/day.
 
* '''Day 1:''' reduce dosage of citalopram/escitalopram to 10 mg/day, resp. 5 mg/day.
 
* '''Day 8:''' stop administration of citalopram/escitalopram.
 
 
| start =  
 
| start =  
* '''Day 8-22:''' a wash-out period of 2 weeks is necessary.
+
 
* '''Day 23:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
+
* '''Day 16:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration.  Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|citalopram}}</ref> {{Lit-SSRI-Hypericum}} {{Lit-SSRI-Hypericum2}}
 +
 
 
| caveat =  
 
| caveat =  
* Occurrence of the serotonin syndrome is possible without wash-out period.
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{{SSRI14d}}
| info =
 
{{HypericumInfo}}
 
  
}}
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| info =
 +
{{HypericumInfo}}}}

Latest revision as of 12:26, 21 October 2015

Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from citalopram to hypericum.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Day 1: reduce dosage of citalopram to a maximum of 20 mg/day
  • Day 8: reduce dosage of citalopram to 10 mg/day
  • Day 15: stop citalopram
Eenrichtingbord.png Start hypericum
  • Day 16: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).[3][4][5][6] [7] [8]
Letopbord.png Cave
  • The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[9]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.
  4. Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.
  5. Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.
  6. KNMP; Informatorium Medicamentorum 2023; Monografie "citalopram" (Dutch)
  7. F. Borelli et al.Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. AAPS J. 2009 Dec;11(4):710-27
  8. Izzo AA. Drug interactions with St John's wort (Hypericum perforatum): a review of the clinical evidence. Int J Clin Pharmacol Ther. 2004 Mar;42(3):139-48
  9. Wurglics M, Schubert-Zsilavecz M.Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.
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