Difference between revisions of "Doxepine-sertraline"

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| to = sertraline  
 
| to = sertraline  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.
+
| start = {{StartAntidepressant}}
* '''Day 8:''' reduce dosage of doxepin to 25 mg/day.
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| info =
* '''Day 15:''' stop administration of doxepin.
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* Safe target dose sertraline = 50 mg
| start =  
+
}}
* '''Day 15:''' start administration of sertraline in a normal dosage of 50 mg/day.
 
* '''Day 22:''' if necessary increase sertraline to 100 mg/day.
 
| info =  
 
* {{theorSS}}
 
* Sertraline is a weak inhibitor of CYP2D6, which metabolizes doxepin.  }}
 

Latest revision as of 11:18, 30 June 2023

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from doxepin to sertraline.[2] [3]

Nietinrijdenbord.png Stop doxepin
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start sertraline
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose sertraline = 50 mg
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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