Difference between revisions of "Combining-Lithium-Gabapentin"
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| − | * | + | * The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding. Since there is little risk of drug interactions, use with lithium is likely to be safe. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref> |
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* Start gabapentine according to the general dosing advice. | * Start gabapentine according to the general dosing advice. | ||
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* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom"> | * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom"> | ||
| − | {{Drugscominteract|lithium-with-gabapentin|lithium|gabapentin}}</ref> | + | {{Drugscominteract|lithium-with-gabapentin-1147-0-1477-0|lithium|gabapentin}}</ref> |
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Latest revision as of 10:59, 25 June 2010
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Adding gabapentin to lithium.
General information- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding. Since there is little risk of drug interactions, use with lithium is likely to be safe. [2]
Start gabapentin- Start gabapentine according to the general dosing advice.
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [3]
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas - lithium (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- ↑ Interactions between lithium and gabapentin on drugs.com
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