Difference between revisions of "Combining-Carbamazepine-Lithium"
From Psychiatrienet
| (7 intermediate revisions by 2 users not shown) | |||
| Line 3: | Line 3: | ||
| add = lithium | | add = lithium | ||
| info = | | info = | ||
| − | * | + | * The available data suggest that the combination of lithium and carbamazepine is safe and effective, especially for rapid-cycling patients.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref> |
| − | * Lithium | + | * Lithium and carbamazepine may work synergistically.<ref name="freeman"/> |
| − | * | + | * Patients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.<ref name="freeman"/> |
| start = | | start = | ||
| − | * | + | * |
| cave = | | cave = | ||
| − | + | {{CombiCaLi}} | |
}} | }} | ||
Latest revision as of 08:49, 23 April 2010
| ||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||
Adding lithium to carbamazepine.
General information- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- The available data suggest that the combination of lithium and carbamazepine is safe and effective, especially for rapid-cycling patients.[5]
- Lithium and carbamazepine may work synergistically.[5]
- Patients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.[5]
Start lithium
Cave- The combination may rarely cause neurotoxicity without increased plasma levels. [6]
- The combination of these two drugs is generally safe and effective, but it should be avoided for patients with comorbid CNS (central nervous system) disease. Cases of neurotoxicity and asterixis have been reported with the concomitant use of lithium and carbamazepine.[5]
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ 3.0 3.1 Farmacotherapeutisch Kompas - carbamazepine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
- ↑ 5.0 5.1 5.2 5.3 Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- ↑ Marcoux AW. Carbamazepine-lithium drug interaction. Ann Pharmacother 1996;30:547
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
