Difference between revisions of "Dosulepine-mianserine"
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| to = mianserine | | to = mianserine | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of dosulpeine to a maximum of 75 mg/day. |
* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day. | * '''Day 1:''' reduce dosage of dosulepine to 50 mg/day. | ||
* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day. | * '''Day 3:''' reduce dosage of dosulepine to 25 mg/day. | ||
| start = | | start = | ||
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* '''Day 1:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day. | * '''Day 1:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day. | ||
* '''Day 8:''' stop administration of dosulepine and continue administration of mianserine. | * '''Day 8:''' stop administration of dosulepine and continue administration of mianserine. | ||
| − | * If necessary, increase dosage of mianserine. }} | + | * '''Day 9:''' If necessary, increase dosage of mianserine. }} |
Latest revision as of 09:48, 17 November 2009
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Switch medication from dosulepine to mianserine.[1] [2]
Stop dosulepine - Before day 1: gradually reduce dosage of dosulpeine to a maximum of 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 3: reduce dosage of dosulepine to 25 mg/day.
Start mianserine- Day 1: simultaneously start administration of mianserine in a low dosage of 30 mg/day.
- Day 8: stop administration of dosulepine and continue administration of mianserine.
- Day 9: If necessary, increase dosage of mianserine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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