Difference between revisions of "Hypericum-venlafaxine"
From Psychiatrienet
(Created page with '{{ Drugswitch | from = hypericum | to = venlafaxine | stop = * Administration of hypericum can be stopped abruptly. | start = * Start administration of venlafaxine the next...') |
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{{ Drugswitch | {{ Drugswitch | ||
| from = hypericum | | from = hypericum | ||
| − | | to = | + | | to = mirtazapine |
| stop = | | stop = | ||
* Administration of hypericum can be stopped abruptly. | * Administration of hypericum can be stopped abruptly. | ||
| start = | | start = | ||
| − | * | + | * '''Day 1-7:''' a wash-out period of one week is necessary. |
| − | * If necessary, increase dosage of venlafaxine.}} | + | * '''Day 8:''' start administration of venlafaxine in a dosage of 37,5 mg/day. |
| + | * '''Day 15:''' increase dosage of venlafaxine to 75 mg/day. | ||
| + | * If necessary, increase dosage of venlafaxine further. | ||
| + | | info = | ||
| + | * Occurence of the serotonin syndrome is theoretically possible. | ||
| + | * Hypericum slows the metabolism of venlafaxine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}} | ||
Revision as of 14:06, 7 May 2009
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Switch medication from hypericum to mirtazapine.[1] [2]
Stop hypericum - Administration of hypericum can be stopped abruptly.
Start mirtazapine- Day 1-7: a wash-out period of one week is necessary.
- Day 8: start administration of venlafaxine in a dosage of 37,5 mg/day.
- Day 15: increase dosage of venlafaxine to 75 mg/day.
- If necessary, increase dosage of venlafaxine further.
More information- Occurence of the serotonin syndrome is theoretically possible.
- Hypericum slows the metabolism of venlafaxine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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