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{{ Drugswitch
| from = hypericum
| to = venlafaxine mirtazapine
| stop =
* Administration of hypericum can be stopped abruptly.
| start =
* Start '''Day 1-7:''' a wash-out period of one week is necessary.* '''Day 8:''' start administration of venlafaxine the next day in a dosage of 37,5 mg/day.* '''Day 15:''' increase dosage of venlafaxine to 75 mg/day.* If necessary, increase dosage of venlafaxinefurther.| info = * Occurence of the serotonin syndrome is theoretically possible.* Hypericum slows the metabolism of venlafaxine via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}
