Difference between revisions of "Mirtazapine-fluvoxamine"
From Psychiatrienet
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* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day. | * '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day. | ||
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day. | * '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day. | ||
| + | * '''Day 8:''' stop administration of mirtazapine. | ||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 8:''' start fluvoxamine in a normal dosage of 50 mg/day. |
| − | * | + | * If necessary, increase dosage of fluvoxamine to 50-100 mg/day. |
| info = | | info = | ||
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP3A4 and CYP2D6.}} | * Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP3A4 and CYP2D6.}} | ||
Revision as of 09:54, 8 May 2009
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Switch medication from mirtazapine to fluvoxamine.[1] [2]
Stop mirtazapine - Day 0: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
- Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
- Day 8: stop administration of mirtazapine.
Start fluvoxamine- Day 8: start fluvoxamine in a normal dosage of 50 mg/day.
- If necessary, increase dosage of fluvoxamine to 50-100 mg/day.
More information- Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP3A4 and CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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