Difference between revisions of "Combining-Ziprasidone-Lamotrigine"
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| − | * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name=" | + | * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscomint"> |
{{Drugscominteract|ziprasidone-with-lamotrigine-2330-0-1430-0|ziprasidone|lamotrigine}}</ref> | {{Drugscominteract|ziprasidone-with-lamotrigine-2330-0-1430-0|ziprasidone|lamotrigine}}</ref> | ||
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Adding lamotrigine to ziprasidone.
General information- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.[4]
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [5]
Start lamotrigine- Start lamotrigine according to the general dosing advice.
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [6]
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
- ↑ Drugs.com lamotrigine
- ↑ Bazire S; Psychotropic drug directory, 2007
- ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- ↑ Interactions between ziprasidone and lamotrigine on drugs.com
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