Adding lamotrigine to ziprasidone.
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Start lamotrigine according to the general dosing advice.
- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. 
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