Difference between revisions of "Vortioxetine-duloxetine"
From Psychiatrienet
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* '''Day 8:''' simultaneously start administration of duloxetine in a low dosage of 30 mg/day. | * '''Day 8:''' simultaneously start administration of duloxetine in a low dosage of 30 mg/day. | ||
| − | * '''Day 15:'''increase the dosage of duloxetine to 60 mg/day. | + | * '''Day 15:''' increase the dosage of duloxetine to 60 mg/day. |
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.}} | * Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.}} | ||
Revision as of 14:45, 3 March 2015
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Switch medication from vortioxetine to duloxetine.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 7: stop administration of vortioxetine.
Start duloxetine- Day 8: simultaneously start administration of duloxetine in a low dosage of 30 mg/day.
- Day 15: increase the dosage of duloxetine to 60 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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