Difference between revisions of "Imipramine-paroxetine"
From Psychiatrienet
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| to = paroxetine | | to = paroxetine | ||
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* '''Day 4:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day. | * '''Day 4:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day. | ||
* '''Day 8:''' stop administration of imipramine and continue administration of paroxetine. | * '''Day 8:''' stop administration of imipramine and continue administration of paroxetine. | ||
| info = | | info = | ||
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* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine. | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine. | ||
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Latest revision as of 13:36, 4 November 2015
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Switch medication from imipramine to paroxetine.[1] [2]
Stop imipramine - Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1-3: reduce dosage of imipramine to 50 mg/day.
- Day 4-7: reduce dosage of imipramine to 25 mg/day.
- Day 8: stop administration of imipramine.
Start paroxetine- Day 4: simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
- Day 8: stop administration of imipramine and continue administration of paroxetine.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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