| to = paroxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.{{stopImipramine}}
| start =
* '''Day 4:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of imipramine and continue administration of paroxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine.
{{review}}
}}