Difference between revisions of "Paroxetine-maprotiline"
From Psychiatrienet
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| start = | | start = | ||
Caution is necessary. | Caution is necessary. | ||
Revision as of 14:49, 30 June 2023
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Switch medication from paroxetine to maprotiline.[1] [2]
Stop paroxetine 
Start maprotilineCaution is necessary.
- Day 9: start administration of maprotiline in a low dosage of 25 mg/day.
- Day 16: increase administration of maprotiline to a dosage of 50-100 mg/day.
More information- "Start low, go slow" is not required, but caution is necessary!
- Paroxetine slows the metabolism of maprotiline via CYP1A2 and CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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