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Paroxetine-maprotiline

224 bytes removed, 14:12, 28 October 2015
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| to = maprotiline
| stop =
* '''Before day 1:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. * '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. * '''Day 8:''' stop dosage of paroxetine.{{stopParoxetine}}
| start =
Caution is necessary.
* '''Day 89:''' start administration of maprotiline in a low dosage of 25 mg/day. * '''Day 1516:''' increase administration of maprotiline to a dosage of 50-100 mg/day. | info =
* "Start low, go slow" is not required, but caution is necessary!
| info =
* Paroxetine slows the metabolism of maprotiline via CYP1A2 and CYP2D6.
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