Combining-Lamotrigine-Carbamazepine

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{{Drugcombi | base = lamotrigine | add = carbamazepine | info =

  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation is recommended for this combination. [1]

| start =

  • Start carbamazepine with a daily dose of 200 mg and increase dose based serum concentration if necessary. Check lamotrigines effect after 2 weeks of therapy and adapt dose if necessary. [2]

| cave =

  • Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
  • Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.