Switch medication from bupropion to nortriptyline.[1]
[2]
Stop bupropion
- Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- Day 1: Stop administration of bupropion
Start nortriptyline
- Day 1-3: start administration of nortriptyline in a low dosage of 25 mg/day.
- Day 4: increase dosage of nortriptyline to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information
- Bupropion slows the metabolism of nortriptyline via CYP2D6.
- Caution is necessary at the start of administration of nortriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop bupropion 
Start nortriptyline
More information